Normalizing dysfunctional purine metabolism accelerates diabetic wound healing
نویسندگان
چکیده
منابع مشابه
Hydrogen sulfide accelerates wound healing in diabetic rats.
AIM The aim of this study was to explore the role of hydrogen sulfide on wound healing in diabetic rats. METHODS Experimental diabetes in rats was induced by intraperitoneal injection of streptozotocin (STZ) (in 0.1 mol/L citrate buffer, Ph 4.5) at dose of 70 mg/kg. Diabetic and age-matched non-diabetic rats were randomly assigned to three groups: untreated diabetic controls (UDC), treated di...
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The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves cardiac performance after myocardial infarction by augmenting the recruitment of endothelial progenitor cells (EPCs) from the bone marrow to the regenerating vasculature. We investigated whether AMD3100 may accelerate diabetes-impaired wound healing through a similar mechanism. Skin wounds were made on the backs of leptin ...
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Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, U.S.A.; *Center for Combat Casualty and Life Sustainment Research, Department of Pathology, USUHS, Bethesda, Maryland, U.S.A.; †Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, Washi...
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BACKGROUND Non-healing foot ulcers are the most common cause of non-traumatic amputation and hospitalization amongst diabetics in the developed world. Impaired wound neovascularization perpetuates a cycle of dysfunctional tissue repair and regeneration. Evidence implicates defective mobilization of marrow-derived progenitor cells (PCs) as a fundamental cause of impaired diabetic neovascularizat...
متن کاملArginine metabolism and wound healing
The dibasic amino acid arginine is of fundamental importance in wound healing as it’s metabolites nitric oxide (NO), proline, and polyamines affect all phases of the wound healing process. In the wound milieu, the concentration of arginine may decrease to undetectable levels and in this context arginine shifts from being a non-essential to a semi-essential amino acid6 as these low concentration...
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ژورنال
عنوان ژورنال: Wound Repair and Regeneration
سال: 2015
ISSN: 1067-1927
DOI: 10.1111/wrr.12249